Original scientific paper

Syntheses of the New Indole Derivatives Related to Indomethacin

M. Mihalić ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
V. Šunjić ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
F. Kajfež ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
V. Čaplar ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
T. Kovač ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy

Abstract

Syntheses and properties of the new indole derivatives 18-33,
being potential antiinflammatoric agents, are described. 1-p-Chlorobenzoyl-
2-methyl-3-(2'-methyl-4'-nitroimidazol-1'-yl)-5-methoxyindole
(32) have been found to possess pronounced antiinflammatoric
activity and very low ulcerogenity. Attempting preparation of
N-benzoylindole derivative 38 via sigmatropic rearrangement of the
open chain precursor 35, as a model procedure for the new synthesis
of indomethacin, very low yields on the desired cyclic product
38 have inevitably been obtained.

Keywords

Hrčak ID:

195983

URI

https://hrcak.srce.hr/195983

Publication date:

26.6.1978.

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