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Acta Pharmaceutica, Vol. 68 No. 3, 2018.

Short communication, Note

https://doi.org/10.2478/acph-2018-0027

Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats

BLANDINA BERNAL-MORALES orcid id orcid.org/0000-0001-5370-4157 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
GABRIEL GUILLÉN-RUIZ orcid id orcid.org/0000-0003-4428-4706 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JONATHAN CUETO-ESCOBEDO orcid id orcid.org/0000-0003-1465-012X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JUAN FRANCISCO RODRÍGUEZ-LANDA orcid id orcid.org/0000-0001-5837-103X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
CARLOS M. CONTRERAS orcid id orcid.org/0000-0002-8471-8989 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México; Unidad Periférica Xalapa, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Neuroetología, Universidad Vera

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Abstract

The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg–1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications.

Keywords

anxiety; diazepam; weaning rats; elevated plus maze; forced swim; open field test

Hrčak ID:

196040

URI

https://hrcak.srce.hr/196040

Publication date:

30.9.2018.

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