Original scientific paper

The Synthesis of the Protected Octapeptide Derivatives with the Sequence of B23-30 Human Insulin Chain

D. Keglević ; Tracer Laboratory, Ruder Boskovic Institute, POB 1016, 41001 Zagreb, and PLIV A PharmaceuticaL and Chemi~aL Works, 41000 Zagreb, Croatia, Yugoslavia
D. Goleš ; Tracer Laboratory, Ruder Boskovic Institute, POB 1016, 41001 Zagreb, and PLIV A PharmaceuticaL and Chemi~aL Works, 41000 Zagreb, Croatia, Yugoslavia
M. Pongračić ; Tracer Laboratory, Ruder Boskovic Institute, POB 1016, 41001 Zagreb, and PLIV A PharmaceuticaL and Chemi~aL Works, 41000 Zagreb, Croatia, Yugoslavia
S. Valenteković ; Tracer Laboratory, Ruder Boskovic Institute, POB 1016, 41001 Zagreb, and PLIV A PharmaceuticaL and Chemi~aL Works, 41000 Zagreb, Croatia, Yugoslavia

Abstract

The fully protected octapeptide VII with the amino acid sequence
of the human insulin B23-ao chain has been synthesized by
the condensation of the N-terminal tripeptide I and C-terminal
pentapeptide VI fragments which were prepared stepwise. The
N-terminal group of VII was protected by the benzyloxycarbonyl
group, whereas all the other functions of VII were blocked by the
use of the tert-butyloxycarbonyl and tert-butyl group, resp~ctively.
Catalytic hydrogenation of VII gave the partially protected octapeptide
VIII.

Keywords

Hrčak ID:

196345

URI

https://hrcak.srce.hr/196345

Publication date:

20.7.1977.

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