Croatica Chemica Acta, Vol. 47 No. 3, 1975.
Conference paper
Survey of Major Points of Interest About Reactions of Cholinesterases
W. N. Aldridge
; Biochemical Mechanisms Section, Toxicology Unit, Medical Research Council Laboratories, Carshaiton, Surrey, Great Britain
Abstract
Three areas of current interest and activity in the study of
the cholinesterases have been chosen for comment:
Aging of phosphorylated cholinesterases. Recent work indicates
that aging (loss of groups attached to the phosphorus) can be brought
about by at least two mechanisms. It now seems probable that
aging is a more general reaction and is not restricted to the cholinesterases. Inhibition by excess substrate and other effects. An attempt has been made to bring together into one model experimental
results from a number of different approaches. These include acceleration of hydrolysis and inhibition by quaternary ammonium
compounds, differences in pH-rate profiles for various substrates
and various inhibitors, substrate inhibition and inhibition by haloxon.
Molecular weight of acetylcholinesterase in membranes. A
recent paper indicating that acetylcholinesterase in membranes is
monomeric is discussed.
Keywords
Hrčak ID:
196587
URI
Publication date:
3.12.1975.
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