Conference paper

Immunization of Rabbits with Purified Nicotinic Acetylcholine Receptor

Ch. Mattsson ; Section of Biochemistry, National Defence Research Institute, Dept. 4, S-172 04 Sundbyberg, Sweden
E. Heilbronn ; Section of Biochemistry, National Defence Research Institute, Dept. 4, S-172 04 Sundbyberg, Sweden

Abstract

Immunization of rabbits, rats and guinea pigs with nicotinic
acetylcholine receptor from the electric organ of T. marmorata
leads to a production of antibodies in these animais. Simultaneously
a peripheral paralysis is seen, particularly .pronounced in rabbits.
In rats the symptoms are transient. The antibody titres in rabbits
are correlated to the visible symptoms. The highest antibody titres
are found in the most affected animals. Electrophysiolog;ical,
immunological and morphological analysis indicate disturbances of
the neuromuscular function, probably on the post.synaptic site.
Thymus reactions may also be involved as a thymit has been found
in the immunized rabbits.

Keywords

Hrčak ID:

196644

URI

https://hrcak.srce.hr/196644

Publication date:

3.12.1975.

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