Medicinski vjesnik, Vol. 20 No. (1), 1988.
Original scientific paper
ERPF in hyperthyroidism
Ivan Karner
Vera Ugrai
Jasna Grdić
Aleksandar Rusić
Cvijeta Margetić
Abstract
ERPF was examined in group of 35 selected patients aged 20—40 years with Grave’s disease. The examination was performed in the stage of florid hyperthyroidism, as well as after achieving stable euthyroid phase during the drug treatment with carbimazole (Favistan). ERPF was determined using the single 131 J injection and simplified blood sampling 20 and 30 minutes post injection for the first, and 40 minutes post injection for the second clearance period (according to Blaufox). The mean value of ERPF in the group of patients with florid hyperthyroidism was 1018.35+ 223.14 ml/min/1.73 m2 in orthostasis, and 1059.3+217.5 ml/min/1.73 m2 in the supine position. After achieving stable euthyroid phase the mean value was 753.42+135.24 ml/min/1.73 m2 in orthostasis, and 795.45+162.20 ml/min/1.73 m2 in the supine position. After achieving stable euthyroid phase the mean value was 753.20+135.24 ml/min/1.73 m2 in orthostasis, and 795.45+162.20 ml/min/1.73 m2 in the supine position. The mean value for the control group of 25 female examinees was 794.53 + 101.35 ml/min/1.73 m2 in orthostasis and 858.78+155.59 ml/min/1.73 m2 in the supine position.
ERPF values are significantly higher in patients with florid hyperthyroidism in comparison to the stable euthyroid phase, as well as to the control group, in orthostasis and in the supine position. Pulse frequency was significantly higher in the florid hyperthyroidism group in comparison to the same patient after achieving stable euthyroid phase and to the control group. We found a significant difference of the systolic blood pressure in orthostasis between the florid hyperthyroidism group and the same patients after achieving stable euthyroid phase. No significant difference was recorded for the diastolic blood pressure values in the supine position in the examined group of patients with hyperthyroidism. Pulse pressure was significantly higher in the florid hyperthyreoidism group in comparison to the same patients after achieving stable euthyroid phase. We estimate it to be a very sensible parameter. It would be necessary to continue the investigation of hyperkinetic circulation in hyperthyroidism because it has some special features, distinct from other hyperkinetic circulation conditions.
Keywords
Hrčak ID:
197075
URI
Publication date:
1.12.1988.
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