Medicinski vjesnik, Vol. 20 No. (1), 1988.
Professional paper
The influence of heparin on the biological distribution of 99mTc-glucoheptonate
Vera Jovanović
Mirjana Jovanović
Tatjana Maksin
Abstract
The influence of heparin as the anticoagulant drug on the radiochemical composition and biological distribution of the renal reagent 99mTc-Glucoheptonate was examined. The interaction of the drug and radiopharmaceutical was examined under »in vitro« conditions, by radiochromatographic method. The increased concentration of heparin caused the decrease of 99mTc-Glucoheptonate fracton and, increased content of 99mTc-heparin fraction. Biological experiment confirmed interaction of drug and radiopharmaceutical also in »in vivo« conditions. Decreased localization of 99mTc-Glucoheptonate in kidneys was observed.
Keywords
biological distribution; 99mTc-Glucoheptonate; heparin
Hrčak ID:
197078
URI
Publication date:
1.12.1988.
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