Short communication, Note

Ketalization of 3-Keto Group of 4-Pregnene-21-ol-3,20-dione and Syntheses of 21-Phenyl-4-pregnene-3,20-dione

U. Valcavi ; Istituto Biochimico Italiano, 20139 Milano, Italia
M. Japelj ; Krka«, Pharmaceutical and Chemical Works, 68000 Novo mesto, Slovenia, Yugoslavia

Abstract

20-Ketosteroids react with ethylene glycol in the presence of
acids more quickly than the i\4-3-keto group. It has been found
that the i\4-3-keto group of 4-pregnene-21-ol-3,20-dione (I) reacts
with ethylene glycol in the presence of pyridine hydrochloriqe
and anhydrous sodium sulfate more quickly than the 20-keto group.
From the so obtained pregnene-21-ol-3,20-dione-3-ethyleneketal
(IV) 21-phenyl-4-pregnene-3,20-dione (VII) was prepared.

Keywords

Hrčak ID:

197198

URI

https://hrcak.srce.hr/197198

Publication date:

20.3.1973.

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