Original scientific paper

Some Studies on the Reaction of B-(N,N-Heptamethylenimino) ethanol with Arylsulphonyl Chlorides

S. Fila-Hromadko ; Research Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
K. Kovačević ; Research Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

In a series of reactions of ~-(N,N-heptamethylenimino) ethanol
with arylsulphonyl chlorides, four groups of compounds having
different structures are described. The reaction in benzene in the
presence of anhydrous sodium carbonate led to the formation
of N,N-bis (heptamethylene)piperazinium salt of the arylsulphonic
acid. When ~-(N,N-heptamethylenimino) ethanol and arylsulphonyl
chloride were reacted in pyridine at o0 the hydrochloride
of W-(N,N-heptamethylenimino) ethyl]-pyridinium-arylsulphonate
was isolated. The same reaction in boiling pyridine gave the
hydrochloride of [~-(N,N-heptamethylenimino) ethyl]-pyridinium
chloride. The p-toluenesulphonic ester of ~-(N,N-heptamethylenimino)
ethanol was prepared by reacting the sodium salt of ~-(N,N-
heptamethylenimino)ethanol ,and p-toluenesulphonyl chloride.
All compounds containing the pyridinium moiety showed strong
hypotensive effect.

Keywords

Hrčak ID:

197319

URI

https://hrcak.srce.hr/197319

Publication date:

10.8.1971.

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