Professional paper

Isolated nodular amyloidosis of the breast associated with monoclonal gamapathy (IgG) - Case report

gabrijela Stanić ; Clinical Hospital "Sveti Duh", Zagreb, Department of Pathology and Cytology
Dubravka Jandrić ; Clinical Hospital "Sveti Duh", Zagreb, Department of Pathology and Cytology
Rosana Troskot Perić ; Clinical Hospital "Sveti Duh", Zagreb, Department of gastroenterology and hepatology;University of Osijek "Josip Juraj Strossmayer"Faculty of Medicine; University of Rijeka, Faculty of Health Studies
Mia Knobloch ; Clinical Hospital "Sveti Duh",Department of gastroenterology and hepatology
Tomislav Pavlović ; Clinical Hospital "Sveti Duh", Zagreb, Department of Radiology

Abstract

Amyloidosis is an abnormal deposition of insoluble amyloid proteins in extracellular spaces. Protein deposits are components of immunoglobulins produced by plasma cells and B–lymphocytes in response to antigenic stimulation. Three different forms of systemic amyloidosis can be distinguished, those are primary (AL), secondary (AA) and family form. Localized amyloidosis occurs in the pancreas in type 2 diabetic patients and in patients on chronic hemodialysis.
Amyloidosis of the breast is a rare entity, mostly involving elderly women, and may be misdiagnosed as carcinoma on mammography.
A 70 years old woman presented with monoclonal IgG gamapathy, hydronephrosis, acute renal insufficiency and suspicious lesion in the breast on ultrasound. Mammography revealed a lobulated, ill demarcated area without visible microcalcifications.

Keywords

amyloidosis; breast; monoclonal IgG gamapathy

Hrčak ID:

198047

URI

https://hrcak.srce.hr/198047

Publication date:

27.3.2018.

Article data in other languages: croatian

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