Reumatizam, Vol. 64 No. 2, 2017.
Review article
EFFECTS OF DIET, LIFESTYLE, AND OTHER ENVIRONMENTAL FACTORS ON THE INCIDENCE OF RHEUMATOID ARTHRITIS
Nadica Laktašić-Žerjavić
Dragica Soldo-Jureša
Porin Perić
Simeon Grazio
Branimir Anić
Abstract
Faced with the diagnosis of a chronic disease such as rheumatoid arthritis (RA), patients oft en wonder whether they themselves have contributed to the development of the disease with their lifestyle and what lifestyle modifications are effective in order to cure the disease. On the other hand, it is important for the public health system to determine the environmental risk factors for the development of RA and to implement specific public health measures aimed at modifying those risk factors, in order to reduce the incidence and, consequently, the prevalence of RA as a chronic disease. New insights into the etiopathogenesis of RA suggest the possibility of an initial autoantibody disease origin from the exstrasynovial tissue, a pathogenic process which seems to be affected by environmental risk factors. In this
review we discuss the possible environmental risk factors important for the development of RA, such as cigarette smoking, chronic infections, lung, gingival, and gut dysbiosis, nutrition, vitamin D status, alcohol and coffee consumption, physical activity, obesity, chronic psychological stress, and socioeconomic status.
Keywords
Arthritis, rheumatoid – etiology, immunology, microbiology; Autoantibodies – immunology; Citrulline – immunology; Peptides, cyclic – immunology; Dysbiosis – immunology, microbiology; Microbiota – immunology; Gastrointestinal microbiome – genetics, immunology; Periodontitis – immunology, microbiology; Bronchiectasis – immunology; Alcohol drinking – adverse effects; Smoking – adverse effects; Obesity – complications; Diet; Exercise; Life style
Hrčak ID:
198811
URI
Publication date:
29.3.2018.
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