Review article
Personalized approach to the therapy of breast cancer
Lidija Beketić Orešković
; Department of Radiotherapy and Internal Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Clinical Oncology, University of Zagreb, School of Medicine, Zagreb, Croatia
Abstract
Personalized therapy of breast cancer is optimal therapeutic approach to the patient, taking into consideration his personal characteristics, as well as clinical characteristics of the malignant disease, involving pathohistological and molecular abnormalities of certain tumor. With the development of molecular oncology methods, genetic profi ling of each individual tumor is possible. Beside the major subtypes of breast carcinoma based on steroide receptors, Ki-67 proliferative index, and HER-2 receptors, numerous genetic subtypes of breast cancer have been found, due to enormous genetic heterogeneity and instability of tumor cells. Some of genetic changes are considered as driving genes, resulting in dysregulations of crucial signaling transduction pathways involving in cell proliferation, angiogenesis, apoptosis, invasion or metastasis. Certain components of signaling transduction pathways can be targeted molecules of so called targeted biological therapy. Understanding of complexities of these dysregulated multiple intracellular signaling cascades in the tumor cells is essential
for the developing of novel potential molecular therapeutic targets.
Keywords
breast cancer; signalling pathways; personalized therapy
Hrčak ID:
199070
URI
Publication date:
29.12.2014.
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