Review article

Učinak Tamoxifen na ženski reproduktivni sustav

Mario Puljiz ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia
Damir Danolić ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia
Ilija Alvir ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia
Ivica Mamić ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia

Abstract

Tamoxifen, trifeniletilenski modulator estrogesnih receptora, se koristi u liječenju raka dojke s pozitvnim estrogenskim receptorima. U tkivu dojke i tumorskim stanica ima estrogen-antagonistički učinak, a u ženskom spolnom sustavu blagi agonistički učinak što se očituje povećanim rizikom od ginekoloških bolesti koje uključuju rak endometrija, hiperplaziju
endometrija, polipe endometrija, adenomiozu, miome, sarkome, polipe vrata maternice i ciste jajnika. Bolesnice s rakom dojke koje se liječe tamoxifenom trebaju biti redovito ginekološki i ultrazvučno pregledavane.

Keywords

tamoxifen; rak dojke; ženski spolni sustav; rak endometrija

Hrčak ID:

199080

URI

https://hrcak.srce.hr/199080

Publication date:

29.12.2014.

Article data in other languages: english

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