Original scientific paper
Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution
Jelena Lović
; ICTM, Department of Electrochemistry, University of Belgrade, Njegoševa 12, 11000, Belgrade, Serbia
Nemanja Trišović
; Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
Jelena Antanasijević
; Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
Milka Avravom Ivić
; ICTM, Department of Electrochemistry, University of Belgrade, Njegoševa 12, 11000, Belgrade, Serbia
Abstract
Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (Au/Cys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10-3, 10-2, 0.1, 0.5, 1 μM and on Au/Cys in a range: 10-3, 10-2, 0.05, 0.1 μM. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.
Keywords
Sildenafil citrate standard; cystein modified electrode; sensitivity; quantitative analysis
Hrčak ID:
200267
URI
Publication date:
15.5.2018.
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