Review article
https://doi.org/10.22514/SV141.052018.2
Can partial splenectomy preserve humoral immunity in pediatric patients? Risks and benefts of partial splenectomy
ANTONIO RUGGIERO
; Division of Pediatric Oncology A. Gemelli Hospital Catholic University of Rome Largo A. Gemelli 8, 00168 Rome, Italy
MARTINA CATALANO
DANIELA RIZZO
PAOLA COCCIA
PALMA MAURIZ
LORENZO NANNI
Abstract
Te spleen plays an important role in removing
normal and abnormal cells from
the blood and in providing an immunologic
response to encapsulated bacteria.
Surgical splenectomy provides efective
treatment for several pediatric disorders,
such as congenital and acquired hemolytic
anemias, abdominal traumas and immunological
and metabolic disorders, but it
is associated with an immediate and lifelong
risk of overwhelming infection. An
alternative to conventional splenectomy is
partial splenectomy, recommended especially
in children younger than 5 years of
age. Recommendations for the prevention
of overwhelming post-total splenectomy
infection include: Pneumococcal, Haemophilus
infuenzae type B and Meningococcal
immunizations, antimicrobial prophylaxis
and prompt antibiotic treatment of
acute febrile illness; conversely, there is no
clear evidence indicating which prevention
measures are to be performed in patients
undergoing partial splenectomy.
Keywords
partial splenectomy; children; immunization
Hrčak ID:
200447
URI
Publication date:
1.6.2018.
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