Review article
https://doi.org/10.21857/ygjwrcjn6y
Colon cancer surgery regarding the differences in prognosis of right- and left-sided colon cancer
Mario Zovak
; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia
Dubravka Mužina Mišić
; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Abstract
Human colon is derived from the embryological midgut and hindgut resulting in the developement of the right and left colon respectively. Right-sided and left-sided colon cancers are not differentiated only based on the embryological origin, anatomical position and clinical manifestations, but there are also numerous studies which prove that heterogeneous genotype features exsist in right and left-sided colon cancers,with distinguishing types of chromosome and microsatellite instability and gene expression patterns. Accumulating evidence suggests that gut microbiota, which differs in right and left colon, also plays an important role in the development of colon cancer. Although the systemic oncologic treatment has changed recently for disseminated left and right colon cancer, the current surgical treatment of both cancer locations for stages I-III follows the same principles of radical surgical oncology and should be executed in the same manner.
Keywords
right- and left-sided colon cancer; microbiota; radical surgical treatment
Hrčak ID:
201086
URI
Publication date:
13.6.2018.
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