Review article
Diagnosis of the Metabolic Insulin Resistance
Diana Muačević-Katanec
Abstract
Insulin resistance is the inability of insulin
to produce its common biological effects at concentrations
effi cient in healthy individuals. It can be related to all aspects
of insulin action. Insulin resistance should be suspected
in patients with a history of diabetes mellitus among
the closest relatives; patients with gestational diabetes
or polycystic ovary syndrome; patients with impaired
glucose tolerance, arterial hypertension, dyslipidaemia
and elevated liver enzymes, as well as in obese patients,
and particularly those with abdominal obesity. As insulin
resistance frequently occurs prior to the development
or diagnosis of different clinical states, its identifi cation
and treatment in the general population have a certain
preventive signifi cance. Several methods are used to
determine the presence and degree of insulin resistance, e.g.
clamp technique, frequently sampled intravenous glucose
tolerance test (FSIVGTT), continuous infusion of glucose
with model assessment (CIGMA), and homeostasis model
assessment (HOMA), which are described in this article.
The most frequently used method today is HOMA, a simple
method for the evaluation of the function of beta cells and
the degree of insulin resistance from basal (fasting) glucose
values and insulin concentrations.
Keywords
metabolic insulin resistance; clamp technique; frequently sampled intravenous glucose tolerance test (FSIVGTT); continuous infusion of glucose with model assessment (CIGMA); HOMA (homeostasis model assessment)
Hrčak ID:
19001
URI
Publication date:
15.11.2004.
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