Original scientific paper

Antimicrobial activity of some hydroxamic acids

STJEPAN PEPELJNJAK
BRANKA ZORC
IVAN BUTULA

Abstract

Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS) (1), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA) (2), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) (3) and poly [alpha,beta-(N-hydroxy)-DL-aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) (4) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophytes species and 3 mould species were used in tests. Compound 1 showed no antimicrobial activity on any of the tested microorganisms. Other compounds (2-4) showed a narrow spectrum of antibacterial activity, but no antifungal activity.

Keywords

hydroxamic acid; polyhydroxamic acid; antimicrobial activity

Hrčak ID:

19045

URI

https://hrcak.srce.hr/19045

Publication date:

1.12.2005.

Article data in other languages: croatian

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