Psychiatria Danubina, Vol. 30 No. 2, 2018.
Original scientific paper
https://doi.org/10.24869/psyd.2018.172
SIGNIFICANTLY LOWER RIGHT MIDDLE CEREBRAL ARTERY BLOOD FLOW VELOCITY IN THE FIRST EPISODE OF PSYCHOSIS DURING NEUROCOGNITIVE TESTING
Ivana Kekin
; Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia
Dina Bosnjak
; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Porin Makaric
; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Zarko Bajic
; Biometrika Healthcare Research, Zagreb, Croatia
Linda Rossini Gajsak
; Neuropsychiatric Hospital “Dr. Ivan Barbot”, Popovaca, Croatia
Branko Malojcic
; Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia; Zagreb School of Medicine, Zagreb, Croatia
Marina Boban
; Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia; Zagreb School of Medicine, Zagreb, Croatia
Martina Rojnic Kuzman
; Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia; Zagreb School of Medicine, Zagreb, Croatia
Abstract
Background: Changes in cerebral hemodynamics have been reported in schizophrenia and proposed as underlying the cognitive
deficits seen in patients. The objective of our study was to compare changes of the cerebral blood flow velocity (BFV) during
neurocognitive tasks between the patients with the first episode of psychosis and healthy controls.
Subjects and methods: We recruited 46 patients with the first episode of psychosis (FEP), admitted to the University Hospital
Centre Zagreb during 2016-2017 and 41 control subjects. Transcranial Doppler ultrasonography monitoring of BFV in both middle
cerebral arteries was recorded during 25-minute long neurocognitive assessment with Phonemic Verbal Fluency test, Trial Making
Test B and Stroop test. Between every consecutive test resting periods were recorded.
Results: After the adjustment for age, sex and education by quantile regression, patients with FEP had significantly lower BFV
in middle cerebral arteries during the 3rd (
Keywords
intracranial blood flow; first psychotic episode; neurocognitive test; neuroimaging; schizophrenia
Hrčak ID:
202065
URI
Publication date:
26.6.2018.
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