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Acta clinica Croatica, Vol. 57. No. 1., 2018.

Other

https://doi.org/10.20471/acc.2018.57.01.24

Undetectable Serum Levels of Anti-Müllerian Hormone in Women with Ovarian Hyperstimulation Syndrome during In Vitro Fertilization and Successful Pregnancy Outcome: Case Report

Ivan Grbavac ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ivana Zec ; Laboratory of Endocrinology, Oncology and Nuclear Medicine Departments, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Dejan Ljiljak ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Romina Rakoš Justament ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Željka Bukovec Megla ; Laboratory of Endocrinology, Oncology and Nuclear Medicine Departments, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Krunoslav Kuna ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

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Abstract

We report a unique case of undetectable serum levels of anti-müllerian hormone (AMH) in women with polycystic ovary syndrome (PCOS) who developed ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF). A case is described of a 28-year-old woman with clinical symptoms of PCOS and AMH serum level below analytical sensitivity (<1.0 pmol/L). After undergoing controlled ovarian stimulation, the patient developed OHSS. After follicle aspiration, seven oocytes were recovered. Three of them were used for intracytoplasmic sperm injection (ICSI) and fertilized, but with unsuccessful pregnancy outcome. A successful pregnancy was achieved in the second IVF/ICSI cycle with six oocytes retrieved and three embryos transferred. At 39 weeks of gestation, the patient delivered a healthy baby weighing 3930 g and 50 cm long. In conclusion, although AMH is considered a useful tool in ovarian reserve assessment and in predicting response to controlled ovarian hyperstimulation, the case presented shows that AMH should not be used as an independent ovarian marker.

Keywords

Infertility; Ovarian hyperstimulation syndrome; Polycystic ovary syndrome; Anti-müllerian hormone; Reproductive techniques, assisted; Case reports

Hrčak ID:

202238

URI

https://hrcak.srce.hr/202238

Publication date:

1.3.2018.

Article data in other languages: croatian

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