Acta Pharmaceutica, Vol. 68 No. 4, 2018.
Original scientific paper
https://doi.org/10.2478/acph-2018-0035
Preparation and characterization of a novel aqueous dispersion for enteric coating of pantoprazole sodium pellets
MIN HAN
; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
QIN YU
; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
XUERONG LIU
; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
FUQIANG HU
; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
HONG YUAN
; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
Abstract
The purpose of this work was to investigate a novel aqueous dispersion (Eudragit® L100-55) for enteric coating of drugs. Three different casting solutions, Eudragit® L100-55 aqueous dispersion, Eudragit® L100-55 organic solution, and Eudragit® L30D-55 aqueous dispersion, were used to prepare free films by the casting method. Drug-loaded pellets, prepared by the extrusion-spheronization method, were coated with one of these three coating solutions using the fluidized-bed spray coating technology. Properties of the free films were thoroughly investigated. Films formed by Eudragit® L100-55 aqueous dispersions showed similar properties to those formed by Eudragit® L100-55 organic solution regarding thermodynamic properties, moisture permeability, solubility and acid tolerance ability. Furthermore, the performance of the novel film was better than that formed by Eudragit® L30D-55 aqueous dispersion. Among the three enteric coating solutions, Eudragit® L100-55 aqueous dispersion will be a promising aqueous dispersion for enteric coating and can be used in the development of enteric-coated preparations.
Keywords
preparation of aqueous dispersion; Eudragit®L100-55; Eudragit®L30D-55; free films; enteric-coated pellets; acid tolerance ability
Hrčak ID:
202266
URI
Publication date:
31.12.2018.
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