Original scientific paper

Early discovery of esophagus adenocarcinoma in Barret's mucosa

Melanija Ražov Radas ; Opća bolnica Zadar, Služba za internu medicinu, Odjel za gastroenterologiju
Nataša Šikić Lisica orcid.org/0000-0003-3371-1151 ; Opća bolnica Zadar, Odjel za patologiju i sudsku mkedicinu

Abstract

The aim of this study was to evaluate the expression of Mucin 2 glycoprotein (MUC2) and Vascular Endothelial Growth Factor (VEGF) in Barrett’s mucosa in association with higher risk for the development of adenocarcinoma (AC). The study included a group of 36 patients with diagnosis of Barrettʹs esophagus (BE) after esophagogastroduodenoscopy, but the pathohistological analysis of esophagogastric junction (EGJ) mucosa showed adenocarcinoma in four patients. The expression of MUC2 and VEGF was performed with immunohistochemistry. MUC2 was expressed in three patients, and VEGF expression was present at three patients in the study, which suggested that angiogenesis could have an important role in replacing normal esophageal mucosa with Barrett’s mucosa.

Keywords

Barrett's esophagus; adenocarcinoma; immunohistochemistry of MUC 2 and VEGF

Hrčak ID:

204588

URI

https://hrcak.srce.hr/204588

Publication date:

20.8.2018.

Article data in other languages: croatian

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