Professional paper

https://doi.org/10.15836/ccar2018.277

Cardiovascular Outcomes and Potential Long-term Benefits of Renal Denervation in Patients with Resistant Hypertension

Marija Magdalena Jakopović ; University of Zagreb School of Medicine, Zagreb, Croatia
Anja Ivošević ; University of Zagreb School of Medicine, Zagreb, Croatia
Marija Stanković ; University of Zagreb School of Medicine, Zagreb, Croatia
Ingrid Prkačin orcid.org/0000-0002-5830-7131 ; University of Zagreb School of Medicine, Zagreb, Croatia; University Hospital «Merkur», Zagreb, Croatia

Abstract

Resistant hypertension is the failure to achieve target blood pressure in spite of using a minimum of 3 antihypertensive drugs of different classes, one of which must be a diuretic, at maximal tolerated doses. The prevalence of true resistant hypertension ranges between 7.9-10.0% and is associated with higher risk of kidney and cardiovascular system damage. Treatment of resistant hypertension focuses on lifestyle modifications and pharmacological therapy. Device-based therapies are
indicated in patients in whom pharmacological agents failed to control the blood pressure. Evidence suggests beneficial effects of renal sympathectomy on life expectancy and prevention of cardiovascular
complications in patients with resistant hypertension with chronic activation of the sympatheticnervous system, such as chronic kidney disease and type 2 diabetes mellitus. In terms of costs, there is no question pharmacoeconomically that effective blood pressure control in resistant hypertension with drugs and new innovative devices therapies is cheaper than treating the consequences of hypertensive target organ damage.

Keywords

resistant hypertension; cardiovascular risk; renal denervation

Hrčak ID:

204777

URI

https://hrcak.srce.hr/204777

Publication date:

3.9.2018.

Article data in other languages: croatian

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