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Psychiatria Danubina, Vol. 30 No. 3, 2018.

Original scientific paper

https://doi.org/10.24869/psyd.2018.310

HOMOCYSTEINE, PYRIDOXINE, FOLATE AND VITAMIN B12 LEVELS IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER

Hatice Altun ; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
Nilfer Sahin ; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Mugla Sıtkı Koçman University, Mugla, Turkey
Ergül Belge Kurutas ; Department of Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
Olcay Güngör ; Department of Pediatric Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

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Abstract

Background: In our study, we aimed to evaluate the serum homocysteine levels, pyridoxine, folate and vitamin B12 levels in children with attention deficit hyperactivity disorders (ADHD).
Subjects and methods: This study included 30 newly diagnosed drug-naive children with ADHD (23 males and 7 female, mean age 9.3±1.8 years) and 30 sex-and age matched healthy controls. The diagnosis of ADHD was made according to DSM-V criteria. Children and adolescents were administered the Schedule for Affective Disorders and Schizophrenia for School Aged Children, Present and Lifetime Version, the Conners' Parent Rating Scale-Revised, Long Form, the Conners' Teacher Rating Scale and the Wechsler Intelligence Scale for Children Revised (WISC-R) for all participants. Homocysteine, pyridoxine, folate and vitamin B12 levels were measured with enzyme-linked immunosorbent assay.
Results: Homocysteine, pyridoxine, folate and vitamin B12 levels were significantly lower in children with ADHD compared with their controls (p<0.05). A positive significant correlation was observed between the all WISC-R scores and vitamin B12 level in patients (r=0.408, p=0.025).
Conclusions: The results obtained in this study showed that reduced homocysteine, pyridoxine, folate and vitamin B12 levels could be a risk factor in the etiology of ADHD.

Keywords

homocysteine; pyridoxine; folate; vitamin B12; attention deficit hyperactivity disorders; children

Hrčak ID:

206434

URI

https://hrcak.srce.hr/206434

Publication date:

1.10.2018.

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