Original scientific paper

https://doi.org/10.11613/BM.2018.030702

Association of abdominal aortic aneurysm diameter with insulin resistance index

Fabien Lareyre ; Department of Vascular Surgery, University Hospital of Nice, Nice, France; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
Claudine Moratal ; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
Elamine Zereg ; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France
Joseph Carboni ; Department of Vascular Surgery, University Hospital of Nice, Nice, France
Patricia Panaïa-Ferrari ; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France
Pascale Bayer ; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France
Elixène Jean-Baptiste ; Department of Vascular Surgery, University Hospital of Nice, Nice, France; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
Réda Hassen-Khodja ; Department of Vascular Surgery, University Hospital of Nice, Nice, France; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
Giulia Chinetti ; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France
Juliette Raffort ; Université Côte d’Azur, CHU, Inserm, C3M, Nice, France; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France

Abstract

Introduction: Epidemiological studies have highlighted a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim
of this study was to investigate the association between insulin resistance and AAA size.
Materials and methods: This prospective cross sectional monocentric study analysed fasting blood samples from 55 patients with AAA eligible
for surgical repair. They were divided into 2 groups according to the median AAA diameter: diameter < 50 mm (N = 28) and diameter > 50 mm (N
= 27). The median ages were respectively 73 years (62 - 79) and 72 years (67 - 81). Glucose and fructosamine concentrations were determined by
spectrophotometry; insulin and C-peptide using chemiluminescent technology. Homeostasis model assessment 2 calculator was used to estimate
insulin resistance index (HOMA2 IR).
Results: There was no significant difference for fasting glucose concentration between the groups (6.1 vs. 5.9 mmol/L, P = 0.825). C-peptide and
insulin concentrations, as well as HOMA2 IR index were significantly higher in patients with AAA > 50 mm (0.82 vs. 0.54 nmol/L, P = 0.012; 9 vs. 5
mU/L, P = 0.019 and 1.72 vs. 1.26, P = 0.028, respectively). No linear correlation was identified between AAA diameter and HOMA2 IR. Fructosamine
concentration was lower in patients with AAA > 50 mm (225.5 vs. 251 μmol/L, P = 0.005) and negatively correlated with AAA diameter (r = - 0.54,
P < 0.001).
Conclusion: This study evidenced an association between AAA diameter and insulin resistance. Further studies are required to determine a causal
link between insulin resistance and AAA development.

Keywords

diabetes mellitus; abdominal aortic aneurysm; C-peptide; insulin resistance; fructosamine

Hrčak ID:

206654

URI

https://hrcak.srce.hr/206654

Publication date:

15.10.2018.

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