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Chemical and Biochemical Engineering Quarterly, Vol. 32 No. 3, 2018.

Original scientific paper

https://doi.org/10.15255/CABEQ.2018.1319

Drug Mass Transfer Mechanism, Thermodynamics, and In Vitro Release Kinetics of Antioxidant-encapsulated Zeolite Microparticles as a Drug Carrier System

Z. Lyubenova Yaneva orcid id orcid.org/0000-0001-8159-4530 ; Chemistry Unit, Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
N. Valkanova Georgieva ; Chemistry Unit, Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
L. Lyubomirova Bekirska ; Chemistry Unit, Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
S. Lavrova ; Faculty of Chemical System Engineering, University of Chemical Technology and Metallurgy, 8, Kliment Ohridski Blvd., Sofia, Bulgaria

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Abstract

The aim of the present study was to develop a new vitamin E-zeolite drug carrier system, and investigate the mass transfer mechanism of the antioxidant encapsulation and release on/from the mineral matrix by thermodynamic and kinetics sorption/desorption experiments and mathematical modelling of the experimental data. The surface, morphological and spectral characteristics of the vitamin and the zeolite were determined by Boehm titration, SEM, FTIR and UV/Vis spectrophotometric analyses. Intraparticle diffusion was not the only rate-limiting mechanism, as the mixed-order kinetics model gave the highest regression coefficient (R2) and lowest SSE, MSE, RMSE, and AICC values. The thermodynamic study confirmed the endothermic nature of the spontaneous encapsulation process and increased degrees of randomness at the solid-liquid interface. The in vitro release results were best modelled by the zero-order and sigmoidal models.
The results obtained are essential for the development of innovative vitamin E-carrier systems for application in human and veterinary medicine.







This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

vitamin E; zeolite; drug encapsulation/release; kinetics; thermodynamics; mathematical modelling

Hrčak ID:

206721

URI

https://hrcak.srce.hr/206721

Publication date:

13.10.2018.

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