Reumatizam, Vol. 65 No. 1, 2018.
Review article
ENTEROPATHIC SPONDYLOARTHRITIS
Fanika Mrsić
Branimir Anić
Abstract
Inflammatory bowel diseases are chronic idiopathic inflammatory diseases of the gastrointestinal tract that may be complicated by a variety of extraintestinal manifestations such as primary sclerosing cholangitis, erythema nodosum, pyoderma gangrenosum, acute anterior uveitis, and aortic insufficiency. However, rheumatological manifestations are the most common, with spondyloarthritis being the most prevalent one. Enteropathic spondyloarthritis can present before, be synchronous with, or aft er the diagnosis of inflammatory bowel disease with two subsets of joint involvement: axial and peripheral. It is believed that genetic, immunological, and environmental factors play a crucial role in the development of enteropathic spondyloarthritis. Although the association between extraintestinal manifestation of symptoms and inflammatory bowel disease is known, the exact pathogenic mechanism and link between articular and gut involvement remains largely unexplained. Future functional studies in this particular field are still needed to elucidate the complex immune mechanism of these interrelated conditions. Early recognition of enteropathic spondyloarthritis in inflammatory bowel disease patients requires a multidisciplinary approach in order to guide therapy, reduce morbidity, prevent future disability, and improve the quality of life in the affected patients.
Keywords
Spondylarthritis; Infl ammatory bowel diseases; Crohn disease; Colitis, ulcerative; Genetic predisposition to disease; Antirheumatic agents; Biological products
Hrčak ID:
207063
URI
Publication date:
16.10.2018.
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