Original scientific paper
https://doi.org/10.21860/medflum2018_207352
Connection between invasive breast cancer characteristics and adipose tissue quantity and distribution in postmenopausal women
Marija Krpina
orcid.org/0000-0002-1295-1175
; Sveučilište u Rijeci, Medicinski fakultet Rijeka, Rijeka
Lucija Knez
; Sveučilište u Rijeci, Medicinski fakultet Rijeka, Rijeka
Andrej Belančić
orcid.org/0000-0001-7848-6600
; Sveučilište u Rijeci, Medicinski fakultet Rijeka, Rijeka
Paula Georgev
; Sveučilište u Rijeci, Medicinski fakultet Rijeka, Rijeka
Martina Demaria
; Sveučilište u Rijeci, Medicinski fakultet Rijeka, Rijeka
Manuela Avirović
; Zavod za patologiju, Sveučilište u Rijeci, Medicinski fakultet, Rijeka
Marina Kosmat
; Zavod za opću kirurgiju, Klinika za kirurgiju, Klinički bolnički centar Rijeka, Rijeka
Franjo Lovasić
; Zavod za opću kirurgiju, Klinika za kirurgiju, Klinički bolnički centar Rijeka, Rijeka
Elvira Mustać
; Zavod za patologiju, Sveučilište u Rijeci, Medicinski fakultet, Rijeka
Abstract
Aim: To investigate a potential connection between breast cancer characteristics and adipose tissue quantity and distribution in postmenopausal women.
Patients and methods: The study included 70 postmenopausal women diagnosed with invasive breast cancer. Overall anthropometric measures (weight, height, waist circumference-WC, hip circumference-HC, body mass index-BMI, waist hip ratio-WHR) and pathohistological data (tumor size, histological grade, estrogen-ER receptor, progesterone-PR receptor, HER2 and Ki67 expression, immunohistochemical tumor type) were collected.
Results: Average age was 65 years (42-86), height 164,8±7,0 cm, weight 75,6±14,5 kg, BMI 27,9±5,3 kg/m2, WC 90,5±12,4 cm, HC 107,6±11,7 cm, WHR 0,84±0,07. Estrogen positive (n=41, 91,1% vs n=18, 72,0%; P=0,037), progesterone positive (n=38, 84,4% vs n=11, 44,0%; P<0,001) and luminal A breast cancers (n=15, 33,3% vs n=2, 8,0%; P=0,019) were significantly more frequent in BMI>25 kg/m2 group. Moreover, estrogen positive (n=52, 88,1% vs n=7, 63,6%; P=0,042), progesterone positive (n=45, 76,3% vs n=4, 36,4%; P=0,008) and luminal A breast cancers (n=17, 28,8% vs n=0, 0%; P=0,042) were significantly more frequent in patients with WC>80 cm, while there was also a significantly lower number of triple negative breast cancers in the latter group (n=1, 1,7% vs n=2, 18,2%; P=0,014).
Conclusions: PR and ER expression positively correlates with adipose tissue quantity, most probably due to higher expression of aromatase.
Keywords
Aromatase; Breast cancer; Estrogen; Obesity; Progesterone
Hrčak ID:
207352
URI
Publication date:
1.12.2018.
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