Original scientific paper

https://doi.org/10.20471/acc.2018.57.02.04

Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma

Jelena Ostojić orcid.org/0000-0002-0314-331X ; Special Hospital for Pulmonary Diseases, Zagreb, Croatia
Luka Brčić ; Medical University of Graz, Institute of Pathology, Graz, Austria
Pero Hrabač ; School of Medicine, University of Zagreb, Croatian Institute for Brain Research, Zagreb, Croatia
Sven Seiwerth ; School of Medicine, University of Zagreb, Zagreb, Croatia; Institute of Pathology and Zagreb University Hospital Centre, Clinical Department of Pathology, Zagreb, Croatia

Abstract

Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium. Th e majority of cases are diagnosed in advanced stage (i.e. stages IIIB and IV), often with scanty amount of tissue in transbronchial biopsies or cytology specimens. Th e aim of the present study was to investigate the expression of the scaff olding protein neural precursor cell expressed, developmentally downregulated 9 (NEDD9) in small biopsies of lung adenocarcinoma. The expression of NEDD9 was analyzed immunohistochemically in 71 formalin-fi xed and paraffin-embedded transbronchial biopsy specimens of primary lung adenocarcinoma. Nuclear and cytoplasmic NEDD9 expression was detected indicating activation of the epithelial-mesenchymal transition process. Direct relationship between the expression of NEDD9 and survival was not
demonstrated.

Keywords

Lung Neoplasms; Adenocarcinoma; Biopsy, Needle; Adaptor Proteins, Signal Transducing; Croatia

Hrčak ID:

207506

URI

https://hrcak.srce.hr/207506

Publication date:

1.6.2018.

Article data in other languages: croatian

Visits: 2.083 *