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Original scientific paper

https://doi.org/10.20471/acc.2018.57.02.04

Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma

Jelena Ostojić orcid id orcid.org/0000-0002-0314-331X ; Special Hospital for Pulmonary Diseases, Zagreb, Croatia
Luka Brčić ; Medical University of Graz, Institute of Pathology, Graz, Austria
Pero Hrabač ; School of Medicine, University of Zagreb, Croatian Institute for Brain Research, Zagreb, Croatia
Sven Seiwerth ; School of Medicine, University of Zagreb, Zagreb, Croatia; Institute of Pathology and Zagreb University Hospital Centre, Clinical Department of Pathology, Zagreb, Croatia


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Abstract

Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium. Th e majority of cases are diagnosed in advanced stage (i.e. stages IIIB and IV), often with scanty amount of tissue in transbronchial biopsies or cytology specimens. Th e aim of the present study was to investigate the expression of the scaff olding protein neural precursor cell expressed, developmentally downregulated 9 (NEDD9) in small biopsies of lung adenocarcinoma. The expression of NEDD9 was analyzed immunohistochemically in 71 formalin-fi xed and paraffin-embedded transbronchial biopsy specimens of primary lung adenocarcinoma. Nuclear and cytoplasmic NEDD9 expression was detected indicating activation of the epithelial-mesenchymal transition process. Direct relationship between the expression of NEDD9 and survival was not
demonstrated.

Keywords

Lung Neoplasms; Adenocarcinoma; Biopsy, Needle; Adaptor Proteins, Signal Transducing; Croatia

Hrčak ID:

207506

URI

https://hrcak.srce.hr/207506

Publication date:

1.6.2018.

Article data in other languages: croatian

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