Acta clinica Croatica, Vol. 57. No. 2., 2018.
Original scientific paper
https://doi.org/10.20471/acc.2018.57.02.09
ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores
Tonći Božin
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Sanda Mustapić
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Tomislav Bokun
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Leonardo Patrlj
; Department of Abdominal Surgery, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia;
Mislav Rakić
; Department of Abdominal Surgery, Dubrava University Hospital, Zagreb, Croatia;
Gorana Aralica
; University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Pathology, Dubrava University Hospital, Zagreb, Croatia;
Milan Kujundžić
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia;
Vladimir Trkulja
; Department of Pharmacology, University of Zagreb, School of Medicine, Zagreb, Croatia
Ivica Grgurević
orcid.org/0000-0003-0520-3483
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;University of Zagreb, School of Medicine, Zagreb, Croatia;
Abstract
The aim of the study was to explore predictive value of the ALBI, PALBI and MELD scores on survival in patients resected for hepatocellular carcinoma with compensated liver cirrhosis and no macrovascular infi ltration. In this retrospective study, longitudinal survival analysis was performed. We analyzed patient/tumor characteristics and MELD, ALBI and PALBI scores as liver function tests for predicting survival outcome. Survival was analyzed from the date of liver resection until death, liver transplantation, or end of follow-up. Patients were stratifi ed for age, cirrhosis etiology, presence of esophageal varices, hepatocellular carcinoma stage, microvascular invasion, histologic diff erentiation, and resection margins. We identifi ed 38 patients (alcoholic cirrhosis in 84.2% of patients) resected over an 8-year period. Median preoperative MELD score was 8, ALBI score -2.63, and PALBI score -2.38. During the follow-up period, 24 patients died. Estimated median survival time was 36 months. Microvascular invasion was observed in 33 patients. Higher ALBI score was associated with 23.1% higher relative risk of death. PALBI score was associated with 12.1% higher relative risk of death, whereas MELD score was not associated with the risk of death. In conclusion, ALBI score demonstrated signifi cant predictive capabilities for survival in patients with compensated cirrhosis resected for hepatocellular carcinoma.
Keywords
Carcinoma, Hepatocellular; Liver Function Tests; Hepatectomy; Liver Transplantation; Esophageal and Gastric Varices; Liver Cirrhosis, Alcoholic
Hrčak ID:
207543
URI
Publication date:
1.6.2018.
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