Short communication, Note

Erythromycin Series. III*. Acylation of Erythromycin Oxime and 9-Amino-3-0-cladinosyl-5-0-desosaminyl-6,11,12-trihydro~y-2,4, 6,8,10,12-hexamethylpentadecane-13-olide with Chlorides of Some Alyphatic Monocarboxylic Acids

Z. Tamburašev ; Research Department •>PLIV A«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
S. Djokić ; Research Department •>PLIV A«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

In our previous publication1 the preparation of mono- and bis-acyl compounds derived from erythromycin oxime and 9-amino-3-0-cladinosyl-5-0- desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane - 13 - olide (erythromycyl amine) and methyl resp. ethyl ester chlorides of succinic and
adipic acid was described. It was found that neither monoacylation nor
diacylation effected a substantial change in the antibiotic activity of the
starting compounds. The sole exception were ethyl succinates and adipates where a lower activity was found. This is in complete agreement with the relative antibiotic activity of erythromycin and its corresponding esters (methylor ethylsuccinate resp. adipate).

Keywords

Hrčak ID:

208054

URI

https://hrcak.srce.hr/208054

Publication date:

1.8.1968.

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