Short communication, Note

The Synthesis of Some Disubstituted Derivatives of p,p'-bis- (Pyrimidyl-2-sulphamyl)-carbanilide. II

B . Glunčić ; Research-Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
K. Dostal ; Research-Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
Z. Crnić ; Research-Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

In an earlier paper1 we' describ ed the preparation of some disub stituted derivatives of p,p'-bis-(sulphamyl)-carbanilide by the condensation of carbanilide- p,p'-disulphbnic acid dichloride with various heterocyclic amines, and their hydrolysis to the corresponding sulphonamides. This paper reports our work <:oncerned with the synthesis of p,p'-bis-(pyrimidyl-2-sulphamyl)-carbanilides
by condensation of p,p'-bis-(N-guanylsulphamyl)-carbanUide with various appropriate s ub stituted aliphatic carbonyl compounds. The preparation was performed according to the standard procedures for the synthesis of substituted .sulphapyrimidines2- 4 and pyrimidines.

Keywords

Hrčak ID:

208165

URI

https://hrcak.srce.hr/208165

Publication date:

25.11.1966.

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