Short communication, Note

Note on the Synthesis of 2-Ethyl-thioisonicotinoylamide

E. Guštak ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
D. Korunčev ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
B. Glunčić ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

Several m ethods for the preparatfon of 2-ethyl-thioi:sornicotinoylamide are reported until now1-s. In our experiments we have prepared the diethylacetal of 2-ethyl-isonicotinalde hyde iby r eaction of trieth:1l0Tthoformate with the crude 2-ethylpyridine-4-magnesium bromide obtained 1by application of a Grignard
type reaction an 2-e thyl-4-bromopyridine. Heating of an aqueous hydrochloric acid solution of the acetal yielded the free 2-ethyl-isonicotinalde hyde6• This was afterwards heated with sulphur and pyridine under conditions of the WillgerodtKindler reaction7 to yield the 2-ethyl-thioisonicotinoyl-·amide .

Keywords

Hrčak ID:

208202

URI

https://hrcak.srce.hr/208202

Publication date:

31.3.1966.

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