Original scientific paper

Hydropyrimidines. I. Synthesis of 5,6-Dihydro-2-thiouracil

B. Gašpert ; Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia
V . Škarić ; Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia

Abstract

The synthesis Gf 5,6-dihydro-2-thiouraoil (I) from 1-(n-
propionic acid ethylester)-3-benzoyl-2-thiourea (IV) was described.
Thioureidoester IV was hydrolyzed in diluted hydrochloric acid and
sodium hydroxide to 1-(n-propionic acid)-3-benzoyl-2-thiourea (V)
and 1-(n-propionic acid)-2-thiourea (homohydantoic acid) (VI)
respectively. IR (5 .85 ; 6.33 μ) and UV (AAmax 225.5 mμ, log e 4.017 ; 270 .5 mμ, log e 4.165) of I revealed the peculiarities by which the tautomeric species of thiohydropyrimidines are distinguished.

Keywords

Hrčak ID:

208334

URI

https://hrcak.srce.hr/208334

Publication date:

30.11.1963.

Visits: 782 *