Preliminary communication

New Method for the Preparation of Arylsulphonylureas

A. Markovac-Prpić ; Research Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
N. Tipić ; Research Department »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

The discovery of the potent hypoglycemic action of N-butyl-N'-sulphanylurea (Carbutamide, I)1 stimulated wide investigations of the chemically related compounds2 but most of them were toxic for human use. However, N-butyl-N'-p-toluenesulphonylurea (Tolbutamide, II) and N-propyl-N'-pchlorobenzenesulphonylurea (Chlorpropamide, III) have been widely used without toxic side effects in the treatment of mild diabetes mellitus of the adult type.

Keywords

Hrčak ID:

208363

URI

https://hrcak.srce.hr/208363

Publication date:

22.4.1963.

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