Original scientific paper

Sulphur-containing Pantothenic Acid Derivatives

S. Kukolja ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
Lj. Polak ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

The synthesis of the mercapto analogue of pantothenic acid
was effected by condensation of thiopantolactone III with ~-alanine.
The required thiopantolactone was obtained by reduction of his
(2,2-dimethyl-3-hydlvoxy-3-carboxypropyl) disulphide or by debenzylation
of S-benzyl-2-hydroxy-4-mercapto-3,3-dimethyl butyric
acid, the latter being prepared by condensaUon of pantolactone with
sodium benzylmercaptide in dimethylformami,de.

Keywords

Hrčak ID:

208381

URI

https://hrcak.srce.hr/208381

Publication date:

15.1.1963.

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