Original scientific paper

Studies in the Propiothiolactone Series. III. Preparation of L-a-Acylamino-B-Propiothiolactones via Carbodiimide Method

M. Dadić ; Pharmaceutical Faculty, University of Zagreb, and »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
D. Fleš ; Pharmaceutical Faculty, University of Zagreb, and »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
A. Markovac-Prpić ; Pharmaceutical Faculty, University of Zagreb, and »Pliva«, Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

N-(p-Toluenesulfonyl)- and N-benzyloxycarbonyl-L-cysteine
were converted to the corresponding propiothiolactones by cyclization
with diisopropyl- and dicyclohexylcarbodiimide in dioxane
at room temperature. The propiothiolactones were condensed
with esters of amino acids to the following protected dipeptides:
bis-(N-p-toluenesulfonyl) - L - cystinyl- di-B-alanine diethyl ester,
bis-(N-p-toluenesulfonyl)-L-cystinyl-diglycine dimethyl ester and
bis-(N -benzy loxycar bony 1)-L-cystiny 1-diglycine dime thy 1 ester.

Keywords

Hrčak ID:

208442

URI

https://hrcak.srce.hr/208442

Publication date:

10.10.1961.

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