Original scientific paper

Substances Acting on the Central Nervous System. III. Synthesis of the Racemic and Optically Active 2-Ethyl-2-phenylglutarimide

S. Kukolja ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
D. Grgurić ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
L. Lopina ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

Condensation of 2-phenylbutyronitrile with acrylonitrile gave
2-ethyl-2-phenyJ.glutaric acid dinitrile which was cyclisized to
2-ethyl-2-phenylglutarimide. 2-Ethyl-2-phenylglutaric acid mononitrile
was resolved with brucine or cinchonidine into optical antipodes
which were converted into the corresponding isomers of
2- ethyl-2-phenylglutarimide and 2 - ethyl - 2- phenylglutaric acid
monoamide.

Keywords

Hrčak ID:

208451

URI

https://hrcak.srce.hr/208451

Publication date:

1.7.1961.

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