Original scientific paper

SUPEROXIDE DISMUTASE ACTIVITY AND SERUM LIPID PROFILE IN HEMODIALYSIS PATIENTS

AMELA BEĆIRAGIĆ ; University Clinical Center Sarajevo, Department of Hemodialysis, Sarajevo, Bosnia and Herzegovina
HALIMA RESIĆ ; University Clinical Center Sarajevo, Department of Hemodialysis, Sarajevo, Bosnia and Herzegovina
AMELA DERVIŠEVIĆ ; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
ALMIR FAJKIĆ ; University of Sarajevo, Faculty of Medicine,Department of Pathophysiology, Sarajevo, Bosnia and Herzegovina
NEJRA PROHIĆ ; University Clinical Center Sarajevo, Department of Hemodialysis, Sarajevo, Bosnia and Herzegovina
NESINA AVDAGIĆ ; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
NERMINA BABIĆ ; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
SELMA AJANOVIĆ ; University Clinical Center Sarajevo, Department of Hemodialysis, Sarajevo, Bosnia and Herzegovina
AIDA ĆORIĆ ; University Clinical Center Sarajevo, Department of Hemodialysis, Sarajevo, Bosnia and Herzegovina

Abstract

Objectives/Aim: Hemodialysis (HD) is associated with a number of biochemical abnormalities including dyslipidemia and oxidative stress. The aim of this study was to evaluate the relationship between serum superoxide dismutase (SOD) activity and lipid profi le in HD patients with different duration of HD treatment. Material and Methods: This cross-sectional study included 100 HD patients that were divided into two subgroups based on the duration of HD therapy: patients on HD for more than three months but less than fi ve years (HD <5 years; n=48) and patients on HD for fi ve years or more (HD ≥5 years; n=52). Control group (n=50) consisted of age- and gender-matched, apparently healthy individuals without subjective and objective indicators of any renal disease. Blood samples were obtained for determination of SOD, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Serum SOD concentration was determined by ELISA method using a commercial kit. Results: Serum concentration of SOD was increased in HD patients when compared to healthy controls. SOD concentration was signifi cantly higher in HD <5 year group compared with control group [12.29 (10.85-14.15) vs.11.04 (9.42 -12.99) U/mL; p<0.05]; however, there was no signifi cant difference in SOD concentration between HD≥5 year group [12.97 (10.27-14.56) U/mL] and healthy control subjects. In addition, there was no significant difference in
serum SOD concentration between HD patients with different duration of dialysis therapy. The levels of TC, LDL and HDL were significantly decreased in both groups of HD patients as compared with control subjects (p<0.0005); however, serum TG levels did not differ significantly between the study groups. According to the ROC analysis, serum levels of TC, LDL and HDL had higher sensitivity than serum SOD concentration in differentiating HD patients from healthy subjects. Conclusions: According to our results, it is concluded that increased serum SOD concentration together with alterations in the lipid profi le enhances the risk of atherosclerosis and favors higher incidence of cardiovascular complications in HD patients.

Keywords

hemodialysis; superoxide dismutase; dyslipidemia

Hrčak ID:

208470

URI

https://hrcak.srce.hr/208470

Publication date:

16.11.2018.

Article data in other languages: croatian

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