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Reumatizam, Vol. 65 No. suppl.1, 2018.

Conference paper

RISK FACTORS FOR EXTRA-ARTICULAR SIGNS IN SPONDYLOARTHRITIS

Hanna Przepiera-Bedzak ; Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Poland
Marek Brzosko ; Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Poland

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Abstract

Background: There are data that development of different extra articular symptoms in seronegative spondyloarthropathies
(SpA) is connected with elevated levels of different markers of inflammatory process
Objectives: The aim the study was to assess risk factors of different extra-articular symptoms in SpA.
Methods: We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin–6 (IL-6), interleukin–18 (IL-18), interleukin–23 (IL-23), endothelin-1 (ET-1)
Results: In SpA patients as compared to healthy controls:
1. Increased serum levels of IL-6 (P=0.02), IL-23 (P=0.03), and Il-18 (P=0.0006) were associated with increased risk of acute anterior uveitis (AAU).
2. Increased serum levels IL-18 (P=0.03) were associated with an increased risk of inflammatory bowel disease (IBD).
3. Increased serum levels of IL-18 (P=0.0002) and decreased serum levels of ET-1 (P=0.006) were associated with increased risk of skin psoriasis.
4. Increased serum levels of IL-18 (P=0.0002) and decreased serum levels of ET-1 (P=0.008) were associated with increased risk of psoriatic onychopathy.
5. Increased serum levels of IL-18 (P=0.01) was associated with increased risk of palmo-plantar pustulosis. SpA patients with AAU (P=0.0008) and IBD (P=0.03) had higher VAS. SpA patients with skin psoriasis (P=0.001) and psoriatic onychopathy(P=0.006) had lower VAS.
Conclusions: In SpA patients, increased serum IL-18 and decreased serum ET-1 were associated with an increased risk of extra-articular symptoms. Increased VAS was connected with AAU and IBD, decreased VAS – with skin psoriasis and psoriatic onychopathy.

Keywords

Hrčak ID:

210541

URI

https://hrcak.srce.hr/210541

Publication date:

5.12.2018.

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