Medicus, Vol. 27 No. 2 Sumamed, 2018.
Original scientific paper
Insights on the Antimicrobial Efficacy of Azithromycin According to the First Croatian Antibiotic Susceptibility Study of Chlamydia Trachomatis Isolates from Genitourinary Tract
Tomislav Meštrović
Sunčanica Ljubin-Sternak
Abstract
Regardless of the fact that antimicrobial resistance represents one of the most pressing issues of modern medicine, thus far chlamydial infection responded well to the first-line therapy i.e. azithromycin. Nonetheless, laboratory-confirmed resistance of sexually-transmitted pathogen Chlamydia trachomatis (C. trachomatis) causing this infection has been repeatedly described in the literature; furthermore, Croatia belongs to the group of countries that exhibit high prescribing rates of azithromycin and other antimicrobial drugs, which can, in turn, give rise to frank resistance or decreased susceptibility. Accordingly, the first Croatian antibiotic susceptibility study of Chlamydia trachomatis aimed to assess in vitro effectiveness of azithromycin and other antibiotics against clinical chlamydial isolates from genitourinary tract. McCoy cell culture model was used to assess minimal inhibitory concentration (MIC) and minimal chlamydicidal concentration (MCC), and all the tested isolates were susceptible to azithromycin (MIC < 4 μg/ml). Although no resistant strains have been found, certain isolates showed significantly higher values of MCC for azithromycin, pointing towards the trend of possible decreased susceptibility. Regardless of the complex methodology, it is pivotal to continue with this kind of resistance surveillance, especially in countries with high antibiotic prescribing rate.
Keywords
Chlamydia trachomatis; sexually transmitted infections; antibiotics; azithromycin; antimicrobial resistance
Hrčak ID:
214612
URI
Publication date:
31.10.2018.
Visits: 976 *