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Acta clinica Croatica, Vol. 57. No. 3., 2018.

Original scientific paper

https://doi.org/10.20471/acc.2018.57.03.03

Influence of the Serotonergic System Polymorphism on the Expression of Dental Anxiety

Tanja Franćeski ; Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Dalibor Karlović orcid id orcid.org/0000-0001-6538-7240 ; Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Vjekoslav Peitl ; Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Rudolf Ljubičić ; Department of Psychiatry, Rijeka University Hospital Centre, Rijeka, Croatia
Ante Silić ; Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Željko Verzak ; School of Dental Medicine, University of Zagreb, Zagreb, Croatia

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Abstract

The aim of the study was to test the correlation between 5-HTTLPR polymorphism and dental anxiety. Research hypothesis was that positive relation between the expression of dental anxiety and the S allele exists in the population of healthy Caucasians. We conducted a prospective study on 159 subjects, volunteers made up of medical and non-medical staff of the Sestre milosrdnice University Hospital Centre. Both genders were included, age range 19 to 59, mentally and physically healthy (according to DSM-5 classification of mental disorders). For the purpose of this research, we used a sociodemographic questionnaire containing the following information: age, gender, education level, work status, marital status and residence. Corah’s Dental Anxiety Scale-Revised (DAS-R) was used to measure dental anxiety. Data distribution was tested by Kolmogorov-Smirnov test, difference between the groups by χ2-test and one-way analysis of variance, and correlation of variables by logistic regression. In the study population, we found positive correlation between S-allele and total result in DAS-R questionnaire. The presence of S allele suggests that the person will have a higher result in DAS-R questionnaire, i.e. higher expression of dental anxiety.

Keywords

Anxiety; Dental anxiety; Polymorphism, genetic; Serotonin plasma membrane transport proteins; Neuroticism; Croatia

Hrčak ID:

216058

URI

https://hrcak.srce.hr/216058

Publication date:

1.9.2018.

Article data in other languages: croatian

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