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Acta clinica Croatica, Vol. 57. No. 3., 2018.

Original scientific paper

https://doi.org/10.20471/acc.2018.57.03.08

Pro-Oxidants and Antioxidants in Retinopathy of Prematurity

Lidija Banjac orcid id orcid.org/0000-0003-0567-041X ; Department of Neonatology, Clinical Center of Montenegro, Podgorica, Montenegro
Goran Banjac ; Institute of Children’s Diseases, Clinical Center of Montenegro, Podgorica, Montenegro
Jelena Kotur-Stevuljević orcid id orcid.org/0000-0002-6980-3069 ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Vesna Spasojević-Kalimanovska ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Tamara Gojković ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Nataša Bogavac-Stanojević ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Zorana Jelić-Ivanović ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Gorica Banjac ; Narodni front Clinic of Gynecology and Obstetrics, Belgrade, Serbia

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Abstract

Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful effects by antioxidants. The proliferative phase 2 ROP occurs at around 33rd postmenstrual week (pmw). The purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33rd pmw. The study included 59 premature infants. ROP was classified according to the International Classification of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. The values of the pro-oxidants TOS and MDA were significantly higher in infants with ROP as compared to infants without ROP (p<0.05 both). There were no significant differences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.

Keywords

Reactive oxygen species; Antioxidants; Retinopathy of prematurity; Infant, premature; Oxidative stress

Hrčak ID:

216117

URI

https://hrcak.srce.hr/216117

Publication date:

1.9.2018.

Article data in other languages: croatian

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