Short communication, Note

https://doi.org/10.2478/acph-2019-0026

Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts

CORINA BUBUEANU orcid.org/0000-0001-5042-4299 ; Department of Pharmaceutical Biotechnology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, Romania
RASIT IUKSEL ; Department of Pharmacology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, Romania
MINERVA PANTELI ; Department of Pharmacology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, Romania

Abstract

Lamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental models in Wistar rats: haemostatic test by tail bleeding time determination and acenocoumarol-carrageenan test. Results of the haemostatic test by tail bleeding determination demonstrated haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the Lamium album extract showed haemostatic activity, comparable to that of vitamin K. Based on the qualitative chemical data on iridoid glycosides (HPTLC), 8-acetylshanzhiside methyl ester might be assumed to be responsible for haemostatic activity. Based on the acute toxicity test, none of the extracts showed toxicity.

Keywords

Lamium album; Lamium purpureum; aerial parts; butanolic extract; haemostatic activity; toxicity

Hrčak ID:

216133

URI

https://hrcak.srce.hr/216133

Publication date:

30.9.2019.

Visits: 2.011 *