Original scientific paper
https://doi.org/10.2478/aiht-2019-70-3214
The effects of occupational lead exposure on selected inflammatory biomarkers
Vugar Ali Turksoy
; Department of Public Health, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey
Lutfiye Tutkun
; Department of Biochemistry, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey
Servet Birgin Iritas
; The Council of Forensic Medicine, Ministry of Justice, Ankara, Turkey
Meside Gunduzoz
; Department of Family Medicine, Ankara Occupational Diseases Hospital, Ankara, Turkey
Serdar Deniz
; Provincial Health Directorate, Malatya, Turkey
Abstract
In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-α) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-α) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Lead levels correlated with IL-6, IL-10, and TNF-α (r=0.469, r=0.521 and r=0.279, respectively, p<0.01) but did not significantly affect h-FABP and VCAM-1 levels.
Keywords
atherosclerosis; cytokines; h-FABP; IL-6; IL-10; TNF-α; VCAM-1
Hrčak ID:
218044
URI
Publication date:
21.3.2019.
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