Professional paper

CHRONIC TRAUMATIC ENCEPHALOPATHY: DIAGNOSTIC CRITERIA AND THERAPEUTIC MODELS

VESNA ŠEPER ; Lavoslav Ružička College of Applied Sciences, Vukovar, Croatia
NEBOJŠA NEŠIĆ ; Lavoslav Ružička College of Applied Sciences, Vukovar, Croatia

Abstract

The aim of the study was to perform systematic review of the existing literature in order to determine new trends regarding diagnostic criteria and therapeutic models of chronic traumatic encephalopathy (CTE). Review of the literature was done during June 2018. PubMed, ScienceDirect and BioMed Central were included in the search. To identify research and review papers dealing with diagnostic criteria and therapy of CTE, the following key words in English were used: chronic traumatic encephalopathy, diagnosis, therapy. The set criteria was met by 23 papers. CTE is a neurodegenerative disease from the group of tauopathies. There is a connection between repeated head trauma and concussion in athletes, most in contact sports, ice hockey, football and basketball. The condition affects middle-aged individuals, as well as athletes several years after repeated trauma to the head and brain. There are no unique diagnostic criteria confi rming CTE, but neuropsychological and neurological exam, blood and cerebrospinal fl uid analysis need to be performed. Magnetic resonance imaging and positron emission tomography scanning is also useful. Therapeutic models include reactive oxygen species inhibitors (ROS; still under investigation), and some additional models such as nutritional interventions, cognitive-behavioral therapy, immunotherapy, hyperbaric therapy, etc.

Keywords

neurodegeneration; tau protein; reactive oxygen species

Hrčak ID:

218965

URI

https://hrcak.srce.hr/218965

Publication date:

4.4.2019.

Article data in other languages: croatian

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