Original scientific paper

https://doi.org/10.20471/acc.2019.58.01.06

Correlation of Peritumoral Brain Edema with Morphological Characteristics and Ki67 Proliferative Index in Resected Intracranial Meningiomas

Hakija Bečulić orcid.org/0000-0002-6904-2490 ; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Rasim Skomorac orcid.org/0000-0002-7085-5720 ; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Aldin Jusić ; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Fahrudin Alić ; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Anes Mašović ; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Eldin Burazerović orcid.org/0000-0002-4273-3937 ; Department of Neurosurgery, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina;
Ibrahim Omerhodžić orcid.org/0000-0001-5143-8801 ; Department of Neurosurgery, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina;
Mirsad Dorić ; Institute of Pathology, Medical Faculty of Sarajevo, Sarajevo, Bosnia and Herzegovina
Melica Imamović orcid.org/0000-0003-2044-551X ; Department of Emergency Medicine, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Alma Mekić-Abazović ; Department of Oncology and Radiotherapy, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Alma Efendić orcid.org/0000-0002-8834-2034 ; Department of Radiology, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Dalma Udovčić-Gagula orcid.org/0000-0003-3047-0962 ; Institute of Pathology, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina

Abstract

The aim of the study was to analyze correlation between morphological characteristics of intracranial meningiomas and Ki67 labeling index (Ki67 LI), and their influence on peritumoral brain edema (PTBE). There were 41 consecutive patients with intracranial meningiomas surgically
treated at the Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina, during the period from January 2010 to December 2015. We reviewed clinical data including patient age, gender, magnetic resonance imaging (MRI) characteristics of the tumor and peritumoral edema, tumor margins, intraoperative characteristics, histopathologic grade and Ki67 LI. In all cases, follow up MRI was obtained at about three months after resection and PTBE was analyzed.
Our research showed the tumor volume, tumor margins, and intraoperative signs of arachnoidal and pial invasion to be associated with PTBE in intracranial meningiomas. Ki67 LI expression correlated
with PTBE. This study showed the resolution of PTBE to depend on invasive behavior of meningioma and KI67 LI. PTBE, pial/cortical and arachnoidal invasion significantly influence the extent of surgical resection.

Keywords

Meningioma; Meningeal neoplasms; Brain edema; Cell proliferation; Ki-67 antigen

Hrčak ID:

220548

URI

https://hrcak.srce.hr/220548

Publication date:

1.3.2019.

Article data in other languages: croatian

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