Original scientific paper

https://doi.org/10.2478/acph-2020-0009

Beneficial effects of baicalein on a model of allergic rhinitis

TAO LIU ; School of Clinical Medicine, Jining Medical University, Jining, Shandong, China; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
JING XU ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
YUNGANG WU ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
XIAOXIA LI ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
DETAO DING ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
DENGDIAN MA ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
MENGWEI YAO ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
WENZHONG WEI ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
WEI ZHANG ; People's Hospital of Hengshu, Hengshui, Hebei, China
SHAOHUA WANG ; Affiliated Hospital of Jining Medical University, Jining, Shandong, China
JING YAO ; School of Basic Medicine, Jining Medical University, Jining, Shandong, China
XIAOYU LI ; School of Clinical Medicine, Jining Medical University, Jining, Shandong, China; Affiliated Hospital of Jining Medical University, Jining, Shandong, China

Abstract

Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.

Keywords

baicalein; ovalbumin; allergic rhinitis; inflammatory factors; p-STAT3

Hrčak ID:

220834

URI

https://hrcak.srce.hr/220834

Publication date:

31.3.2020.

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