Original scientific paper

https://doi.org/10.2478/acph-2020-0010

Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets

MARILENA VLACHOU ; Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
EFTHYMIA GERANIOU ; Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
ANGELIKI SIAMIDI ; Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens

Abstract

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®. Moreover, furosemide release in the intestinal pH from matrix tablets and compression coated tablets was not noticeably different. Formulations incorporating PEO led to sustained release, in intestinal fluids, which depended on the molecular weight of PEO.

Keywords

matrix tablets; compression coated tablets; furosemide; Eudragit®; poly(ethylene oxide); polyvinylpyrrolidone

Hrčak ID:

220835

URI

https://hrcak.srce.hr/220835

Publication date:

31.3.2020.

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