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Acta Pharmaceutica, Vol. 70 No. 1, 2020.

Original scientific paper

https://doi.org/10.2478/acph-2020-0011

Branched PLGA derivatives with tailored drug delivery properties

EVA SNEJDROVA ; Charles University, Faculty of Pharmacy, 500 05 Hradec Kralove, Czech Republic
STEPAN PODZIMEK ; SYNPO, 532 07 Pardubice, Czech Republic; Wyatt Technology Europe, 56307 Dernbach, Germany; Institute of Chemistry and Technology of Macromolecular Materials, University of Pardubice, 532 10 Pardubice, Czech Republic
JURAJ MARTISKA orcid id orcid.org/0000-0001-5287-6192 ; Charles University, Faculty of Pharmacy, 500 05 Hradec Kralove, Czech Republic
ONDREJ HOLAS ; Charles University, Faculty of Pharmacy, 500 05 Hradec Kralove, Czech Republic
MILAN DITTRICH ; Charles University, Faculty of Pharmacy, 500 05 Hradec Kralove, Czech Republic

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Abstract

Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic-co-glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. A series of poly(lactic-co-glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid. The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties.

Keywords

PLGA; branching; star polymer; polymer synthesis; light scattering

Hrčak ID:

220836

URI

https://hrcak.srce.hr/220836

Publication date:

31.3.2020.

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